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Chondroguard

Composition: One ampoule contains: Active ingredient: chondroitin sulphate sodium — 100 or 200 mg. Excipients: benzyl alcohol, sodium metabisulphite, sodium hydroxide, water for injections.

Form: Solution for intramuscular and intra-articular administration.

Indications: Degenerative and dystrophic diseases of the joints and spine: • Osteoarthritis of peripheral joints. • Intervertebral osteochondrosis and osteoarthritis. To accelerate bone callus formation in fractures.

Contraindications: • Hypersensitivity to the medicine or its components. • Bleeding and a tendency to bleed. • Thrombophlebitis. • For intra-articular administration: active inflammatory or infectious processes in the joint, active skin disease or skin infection at the intended injection site. • Childhood. • Pregnancy and breastfeeding (safety data are currently unavailable).

Dosage: Administer 100 mg intramuscularly every other day. If well tolerated, increase to 200 mg from the fourth injection. The course is 25–30 injections. If necessary, a repeat course may be given after 6 months. In osteoarthritis of large joints, intra-articular and intramuscular administration may be combined: up to 5 intra-articular injections of 200 mg, with a 3-day interval between administrations, and 16 intramuscular injections of 200 mg every other day. Intra-articular administration is performed under aseptic conditions by a specialist trained in the technique. Depending on joint size, up to 2 ml of Chondroguard® may be injected into the joint cavity. After injection, wipe the puncture site with an alcohol swab and apply a bactericidal plaster. For bone callus formation, the course lasts 3–4 weeks (10–14 injections every other day).

Side effects: Local reactions (redness, itching), allergy, rarely — bleeding at the injection site.

Interactions: Enhances the effect of anticoagulants, antiplatelet agents, and fibrinolytics. Coagulation monitoring is required when used together.

Warnings: Intra-articular injection must be performed by a specialist. Use with caution in patients prone to bleeding. Prescription only.

Age restrictions: 18+

Pregnancy: Contraindicated during pregnancy and lactation.

Country of origin: Russia

Manufacturer: Sotex

Storage conditions: Store at a temperature not exceeding 25°C, protected from light. Do not freeze. Keep out of reach of children.

Clinical studies:

Molecular effects of Chondroguard in osteoarthritis and intervertebral disc herniation

Neurology, Neuropsychiatry, Psychosomatics, 2017

Authors: Lila A.M., Gromova O.A., Torshin I.Yu., Nazarenko A.G., Gogolev A.Yu.

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Portrait of a patient with pain syndrome. Different therapy approaches depending on pain localization and patient age

Russian Medical Journal, 2021

Authors: O.A. Shavlovskaya

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Experience in the comprehensive treatment of discogenic radiculopathies in athletes

Medical Council, 2017

Authors: O.G. Gutyanskiy, PhD A.A. Chestnov

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Injectable form of chondroitin sulfate in neurological practice

Journal of Neurology and Psychiatry, 2019

Authors: O.A. Shavlovskaya, S.L. Kuznetsov

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On clinical guidelines for osteoarthritis: why do different countries have different strategies?

Russian Medical Journal, 2017

Authors: A.V. Naumov, PhD N.O. Khovasova

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Comparative effectiveness of injectable and oral symptomatic slow-acting drugs in the treatment of primary and post-traumatic osteoarthritis of the knee joints

Russian Medical Journal, 2016

Authors: M.I. Udovika

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